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Our Lab investigates how saliva modulates bacterial colonization in the mouth

Research in our laboratory investigates the molecular mechanisms of initial bacterial attachment to teeth, tissue, or biomaterial surfaces in the mouth. We try to unravel the molecular mechanisms of how glycoproteins in saliva or on host cells are recognized by glycan-binding microbial adhesins. It is our long-term goal to better understand the modulating role of saliva in supporting colonization of the human oral cavity by a benign commensal microbiota, and in host defense against pathogenic microorganisms. More recently, our research involves the investigation of evolutionary mechanisms that have shaped host-microbial interactions in the human mouth. Learn more about our research and areas of study below.

Glycan-Mediated Bacterial Adhesion in the Mouth

Evolution of Salivary Proteins

Biomaterial Surface Modification

Proteins and Glycoproteins in Saliva

Contact Us

Stefan Ruhl, D.D.S., Ph.D.
University at Buffalo
School of Dental Medicine
Department of Oral Biology
3435 Main Street
UB-South Campus, Foster Hall, Rm. 213A
Buffalo, NY 14214-3092


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